J F Kennedy (EDT), G O Phillips (EDT), P A Williams (EDT), V C Hascall (EDT) Hyaluronan

Annotation

Hyaluronan and its derivatives has developed very quickly in the last few years from a scientific novelty into an important new material for a diverse range of medical and biomaterial applications. This landmark conference focused on developments and applications in the use of hyaluronan in tissue repair and reconstruction, drug delivery systems, anti-cancer treatments and joint recovery and engineering.The entire range of hyaluronan progress is covered in depth by the more than 135 individual papers:Analytical chemistryStructural elucidation and basic chemistryElectron microscopy and atomic force microscopyProduction, purification and characterisationQuality in production systemsChemical modificationDerivatives and propertiesCross-linkingFree radical modificationPhysical characterisationRheologyAggregation phenomenaInteraction with water and solution propertiesCell biologyControl and regulation of HA synthasesCell surface chemistryHA cell receptors and cell signallingInteraction with proteins and other biological ligandsBiophysical aspectsEffects on pain receptorsNeurobiologyRole in organisation of extracellular matrixRole in development (embryogenesis): cell movement/migrationMedical applicationsUses in cartilage and wound repairInflammationWound regenerative healingSurgery and tissue engineeringViscosupplementation / osteoarthritisViscoaugmentation and viscoprotectionAnti-adhesion applicationsBrug delivery systemsBinding onto tumour cells and metastasesOutlines the proceedings of the landmark conference which focused on key developments and applications in the use of hyaluronan in tissue repair and reconstruction, among other usesThe entire range of hyaluronan processes is dealt with in depth by more than 135 individual papers presented in two volumesCovers analytical chemistry, chemical modification, physical characterisation, cell biology and medical applications