Ubiquitin Ligase
New Insights, Emerging Roles and Clinical Implications
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The E3 ubiquitin ligases facilitate substrate specificity and isopeptide bond formation between C-terminal glycine residue of ubiquitin (Gly 76) and a lysine residue in the target protein. This book reviews several new insights, discusses emerging roles and analyzes clinical implications of uniquitin ligases.
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