Charles G. Cochrane (EDT), Michael A. Gimbrone (EDT) Biological Oxidants: Generation and Injurious Consequences

Annotation

Biological Oxidants: Generation and Injurious Consequences is a collection of papers that describes research work done concerning molecules of the intracellular and plasma membrane generating system in leukocytes; the intracellular interactions in oxidant-induced cellular injury; malignant transformation; and intracellular mechanism of oxidant formation. One paper reviews biological oxidants and the molecular basis of chronic granulomatous disease, particularly on compositions found within the plasma membrane. One such composition concerns the discovery of a flavocytochrome b as the central electron-transporting molecule in this system. Another paper examines the early injury of cells caused by external oxidants and the consequences of DNA damage. Other papers review the metabolism of vascular endothelial-derived reactive species, the calcium-modulated cellular effects of oxidants, as well as, the mechanism of inflammatory oxidant damage in tissues. This book is suitable for biochemists, microbiologists, and academicians whose works involve research of cell membranes.